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Computional Biomedicine Lecture - Shared screen with speaker view
Samuel Gunz
14:37
Okay I will ask in the TA session today. But thank you :)
Mirko De Vita
15:00
20CBM20 , it works for me
Polina Suter
22:16
cancer: mutations and copy number changes in the DNA cause changes in gene and protein expression levels perturbing normal functioning of the cells
Polina Suter
22:38
we want to know which changes exactly cause tutors and which are “benign”
Polina Suter
22:47
*tumors
Dominik Vincent Cornelius Hollidt
22:53
Maybe the function are broken. If you could measure the DNA and also the RNA you could see how many mutations you would get in between
Samuel Gunz
23:31
1. Understand if a disease is caused by an error in transcription or translation or neither of bot and 2. ideally understand where the error happens exactly in order to find possible treatments/interventions.
Dominik Vincent Cornelius Hollidt
33:57
what is a binding Zone?
Dominik Vincent Cornelius Hollidt
35:02
yes
Dominik Vincent Cornelius Hollidt
36:04
what is a somatic mutation
Emanuel Peter
37:16
this means only a part of your cells have the mutation
Chenxi Nie
37:19
But how should we know that this mutation really leads to cancer rather than other phenotypes that is different from us , say eye colour?
Dominik Vincent Cornelius Hollidt
38:15
how can one distinguish cancer from random mutations, which dont do anything.
Chenxi Nie
39:48
Yes, thanks
Dominik Vincent Cornelius Hollidt
39:51
what can you do with the information what gene caused the cancer?
Polina Suter
01:17:18
change the order of normalization?
Mirko De Vita
01:17:36
Probably is the average RPKM is not the same across different samples
Mirko De Vita
01:18:21
Because few transcripts dominate
Emanuel Peter
01:32:36
For the flow we have to drop the square though, right?
Emanuel Peter
01:33:04
Why do we do the squared error anyway?
Emanuel Peter
01:34:07
alright, thanks
Emanuel Peter
01:56:54
thank you :)
Polina Suter
01:56:55
Thanks for the lecture!
Mirko De Vita
01:56:58
Thanks!
Dhruv Agrawal
01:57:05
Thanks!
Piersilvio De Bartolomeis
01:57:06
Thanks!